From the north — including Southwest Florida International Airport (RSW, about 50 minutes) and other points along I-75 — take I-75 south to Exit 101 (Collier Blvd / Route 951). Cross the Judge S. S. Jolley Bridge onto the island, and continue south on Collier Blvd until the road curves near Cape Marco. The Apollo is on the right just before the public beach access pathway and that bend.
From the east — including Miami (MIA, about 2 hours), Fort Lauderdale (FLL, about 2 hours), and Palm Beach (PBI, about 3 hours) airports, and other areas on Florida’s east coast — take either I-75 or US-41. I-75 follows the same route as above after taking Exit 101. On US-41, turn left onto San Marco Road, cross the Goodland Bridge, and continue until San Marco ends at Collier Blvd. Turn left on Collier Blvd and continue south; the Apollo will be on the right just before the bend.